Mebendazole

1. Chemical Name: methyl 5-benzoylbenzimidazole-2-carbamate

2. Molecular Formula:C₁₆H₁₃N₃O₃

3. CAS No.: 31431-39-7

4. Pharmacodynamic Properties:

Mebendazole is a broad-spectrum anthelmintic, it is strongly bound to the worm’s beta microtubules protein tubulin under very low concentration. It interferes with the carbohydrate metabolism and associated energy production of the parasite, inhibits the polymerization of microtubules, and eventually causes selective disappearance of cytoplasmic microtubules in the tegumental and intestinal cells and the slow immobilization and death of the worms by selectively and irreversibly blocking uptake of glucose and other nutrients in susceptible intestine where helminthes dwell. It is also an uncoupler of the mitochondrial oxidative phosphorylation resulting in inhibition of the mitochondrial fumarate reductase and impairing glucose transferring and ATP-synthesis. It is used to treat infections caused by worms such as whipworm, pinworm, roundworm, and hookworm in humans and animals.. It is also used to treat infections caused by more than one of these worms at the same time. Mebendazole is not effective for hydatid disease.

5. Storage: Keep container tightly closed in a cool, well-ventilated area.

6. Specification: EP/USP/CP

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